Kimiyuki Shibuya Selected Research

(2- (4- (2- benzimidazol- 2ylthio)ethyl)piperazin- 1yl)- N- (2,4- bis(methylthio)- 6- methyl- 3- pyridyl)acetamide

10/2019	Brain Targeting of Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor K-604 via the Intranasal Route Using a Hydroxycarboxylic Acid Solution.
11/2010	A selective ACAT-1 inhibitor, K-604, stimulates collagen production in cultured smooth muscle cells and alters plaque phenotype in apolipoprotein E-knockout mice.
4/2007	A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels.

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Kimiyuki Shibuya Research Topics

Disease

3	Atherosclerosis 07/2015 - 04/2007
1	Glioblastoma (Glioblastoma Multiforme) 10/2019
1	Alzheimer Disease (Alzheimer's Disease) 10/2019
1	Neuroblastoma 11/2016
1	Cardiovascular Diseases (Cardiovascular Disease) 07/2015
1	Dyslipidemias (Dyslipidemia) 07/2015
1	Atherosclerotic Plaque (Atheroma) 11/2010

Drug/Important Bio-Agent (IBA)

4	CholesterolIBA 10/2019 - 04/2007
3	(2- (4- (2- benzimidazol- 2ylthio)ethyl)piperazin- 1yl)- N- (2,4- bis(methylthio)- 6- methyl- 3- pyridyl)acetamideIBA 10/2019 - 04/2007
2	Acyl Coenzyme A (Acyl CoA)IBA 10/2019 - 11/2010
1	Pharmaceutical PreparationsIBA 10/2019
1	EstersIBA 11/2016
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 11/2016
1	Arachidonic Acid (Vitamin F)IBA 11/2016
1	Linoleic Acid (Linoleate)IBA 11/2016
1	Oleic Acid (Oleate)IBA 11/2016
1	HDL CholesterolIBA 07/2015
1	LDL CholesterolIBA 07/2015
1	CollagenIBA 11/2010

Therapy/Procedure

1	Therapeutics 07/2015